Gabapentin is a pharmaceutical drug that has a white solid (small crystals) physical appearance. The molecular formula of gabapentin is C9H17NO2, and it has a formula weight of 171.23678 g/mol. It has diverse brand names such as Gralise, Neurontin, Fanatrex and Horizant (National Center for Biotechnology Information).
Commercially, gabapentin can be obtained in the forms of capsules or tablets of diverse doses (capsules: 100, 300 and 400 mg; tablets: 300, 600 and 800 mg; webpage of the United States National Library of Medicine).
Gabapentin has various pharmacokinetic and pharmacodynamic properties. Compared to pregabalin, gabapentin is absorbed slowly after oral administration, and it has an utmost level in plasma within 3–4 hours. Besides this, oral administration of gabapentin has a saturable absorption (a nonlinear process, zero order).
Furthermore, the plasma level of gabapentin does not increase proportionally if its dosages are increased; gabapentin does not attach to plasma proteins.
Gabapentin is neither inhibited nor metabolized by hepatic enzymes; besides, gabapentin can be expelled by the renal system, and its excretion half-life is roughly 6 hours.
Antacids reduce the concentration of gabapentin in blood. Therefore, gabapentin should be administered 2 hours or more after taking antacids.
Morphine significantly increases blood concentrations of gabapentin and may increase central nervous system-related adverse events associated with gabapentin.
Common medications checked in combination with gabapentin
- Advair Diskus (fluticasone / salmeterol)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Celebrex (celecoxib)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Lantus (insulin glargine)
- Lasix (furosemide)
- Lipitor (atorvastatin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Plavix (clopidogrel)
- Synthroid (levothyroxine)
- Vicodin (acetaminophen / hydrocodone)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
Medications known to interact with gabapentin
Note: Showing generic names only.
- acetylcarbromal
- alfentanil
- alprazolam
- aluminum hydroxide
- amitriptyline
- amobarbital
- amoxapine
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- asenapine
- azatadine
- baclofen
- benztropine
- biperiden
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- buspirone
- butabarbital
- butalbital
- butorphanol
- cannabidiol
- cannabis
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cimetidine
- citalopram
- clemastine
- clobazam
- clomipramine
- clonidine
- clorazepate
- clozapine
- codeine
- colesevelam
- cyclobenzaprine
- cyproheptadine
- dantrolene
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- difelikefalin
- dihydroxyaluminum sodium carbonate
- diphenhydramine
- divalproex sodium
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- entacapone
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- evening primrose
- ezogabine
- felbamate
- fentanyl
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosphenytoin
- ginkgo
- halazepam
- haloperidol
- heroin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyzine
- iloperidone
- imipramine
- isocarboxazid
- kava
- ketamine
- lamotrigine
- lasmiditan
- lemborexant
- levocetirizine
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lithium
- lofexidine
- loxapine
- lumateperone
- lurasidone
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- maprotiline
- mefloquine
- meperidine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methocarbamol
- metoclopramide
- metyrosine
- midazolam
- milnacipran
- mirtazapine
- molindone
- morphine
- morphine liposomal
- nabilone
- nalbuphine
- nefazodone
- nortriptyline
- olanzapine
- oliceridine
- olopatadine nasal
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
- paliperidone
- paraldehyde
- paroxetine
- pemoline
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- phenelzine
- phenobarbital
- phenytoin
- pimozide
- pramipexole
- pregabalin
- primidone
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propoxyphene
- protriptyline
- pyrilamine
- quazepam
- quetiapine
- ramelteon
- rasagiline
- remifentanil
- risperidone
- ropinirole
- rotigotine
- rufinamide
- secobarbital
- sertraline
- sibutramine
- sodium oxybate
- st. john’s wort
- stiripentol
- sufentanil
- suvorexant
- tapentadol
- tasimelteon
- temazepam
- tetrabenazine
- thalidomide
- thioridazine
- thiothixene
- tizanidine
- tolcapone
- tramadol
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- valbenazine
- valerian
- venlafaxine
- vigabatrin
- vilazodone
- vortioxetine
- zaleplon
- ziconotide
- ziprasidone
- zolpidem