Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage.
Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.
Current Situation Acetaminophen can be purchased OTC in large amounts, including bottles that contain hundreds of doses. Options More than one potential option exists under…
Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar…
Acetaminophen is fever reducer and pain reliever. It is used for treating many conditions like colds, backache, fevers, muscle aches, headache, toothaches and arthritis. Acetaminophen…
There are a lot of manufacturers can produce Acetaminophen. The Main Manufacturers are: Ortho mcneil pharmaceutical inc G and w laboratories inc Able laboratories inc…
Taking too much acetaminophen can cause liver damage, sometimes serious enough to require liver transplantation or cause death. You might accidentally take too much acetaminophen…
Cholic Acid The serum concentration of Acetaminophen can be decreased when it is combined with Cholic Acid. Approved Cholestyramine Cholestyramine can cause a decrease in…
Ezetimibe The serum concentration of Ezetimibe can be increased when it is combined with Acetaminophen. Approved Everolimus The serum concentration of Everolimus can be increased…
Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…
Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…
Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…