In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.

In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.

Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders.

It has a wide therapeutic index, with doses in excess of 8000 mg/kg failing to cause a fatal reaction in rats

Gabapentin is ineffective in absence seizures and should be used in caution in patients with mixed seizure disorders involving absence seizures.

Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms (DRESS), otherwise known as multi-organ hypersensitivity. This reaction can prove fatal and early symptoms such as fever, lymphadenopathy, and rash should be promptly investigated.

 

Gabapentin Manufacturers:

Actavis elizabeth llc
Amneal pharmaceuticals ny llc
Apotex inc etobicoke site
Aurobindo pharma usa inc
Hikma pharmaceuticals
Invagen pharmaceuticals inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Mutual pharmaceutical co inc
Ranbaxy laboratories ltd
Sandoz inc
Sun pharmaceutical industries ltd
Teva pharmaceuticals usa
Watson laboratories inc
Pfizer pharmaceuticals ltd
Parke davis div warner lambert co
Glenmark generics ltd
Matrix laboratories ltd
Teva pharmaceuticals usa inc

Gabapentin Packagers

• 4uOrtho LLC
• Actavis Group
• Aidarex Pharmacuticals LLC
• Amerisource Health Services Corp.
• Amneal Pharmaceuticals
• Apotex Inc.
• Apotheca Inc.
• A-S Medication Solutions LLC
• Aurobindo Pharma Ltd.
• Blenheim Pharmacal
• Blu Pharmaceuticals LLC
• Bryant Ranch Prepack
• Camber Pharmaceuticals Inc.
• Cardinal Health
• Comprehensive Consultant Services Inc.
• Corepharma LLC
• Coupler Enterprises Inc.
• Dispensing Solutions
• Diversified Healthcare Services Inc.
• Eon Labs
• Fusion Pharmaceuticals LLC
• Glenmark Generics Ltd.
• Golden State Medical Supply Inc.
• Greenstone LLC
• H.J. Harkins Co. Inc.
• Heartland Repack Services LLC
• Hikma Pharmaceuticals
• Innoviant Pharmacy Inc.
• Ivax Pharmaceuticals
• Kaiser Foundation Hospital
• Keltman Pharmaceuticals Inc.
• Lake Erie Medical and Surgical Supply
• Living Well Pharmacy Inc.
• Major Pharmaceuticals
• Mckesson Corp.
• Medvantx Inc.
• Murfreesboro Pharmaceutical Nursing Supply
• Mylan
• Neuman Distributors Inc.
• Northstar Rx LLC
• Nucare Pharmaceuticals Inc.
• Palmetto Pharmaceuticals Inc.
• PCA LLC
• PD-Rx Pharmaceuticals Inc.
• Pfizer Inc.
• Pharmaceutical Packaging Center
• Pharmacy Service Center
• Physicians Total Care Inc.
• Preferred Pharmaceuticals Inc.
• Prepak Systems Inc.
• Professional Co.
• Ranbaxy Laboratories
• Rebel Distributors Corp.
• Remedy Repack
• Resource Optimization and Innovation LLC
• Sandhills Packaging Inc.
• Southwood Pharmaceuticals
• St Mary’s Medical Park Pharmacy
• Stat Rx Usa
• Sun Pharmaceutical Industries Ltd.
• Teva Pharmaceutical Industries Ltd.
• UDL Laboratories
• United Research Laboratories Inc.
• Vangard Labs Inc.
• Warner Lambert Company LLC
• West-Ward Pharmaceuticals

Because there are more than fifty packagers in the market. There are more gabapentin shapes and pictures that do not display on this page. But all our prescriptions are distributed by US licensed pharmacies and reviewed by US licensed pharmacists.

If your Gabapentin pictures are not show here and you can check google image for it. If it is not in google images and please let us know and I will tell the pharmacies.

Gabapentin mechanism of action

The precise mechanism through which gabapentin exerts its therapeutic effects is unclear.

The primary mode of action appears to be at the auxillary α2δ-1 subunit of voltage-gated calcium channels (though a low affinity for the α2δ-2 subunit has also been reported).

The major function of these subunits is to facilitate the movement of pore-forming α1 subunits of calcium channels from the endoplasmic reticulum to the cell membrane of pre-synaptic neurons.

There is evidence that chronic pain states can cause an increase in the expression of α2δ subunits and that these changes correlate with hyperalgesia.

Gabapentin appears to inhibit the action of α2δ-1 subunits, thus decreasing the density of pre-synaptic voltage-gated calcium channels and subsequent release of excitatory neurotransmitters.

It is likely that this inhibition is also responsible for the anti-epileptic action of gabapentin.

There is some evidence that gabapentin also acts on adenosine receptors and voltage-gated potassium channels, though the clinical relevance of its action at these sites is unclear.