• Nonprescription migraine medication for mild, moderate, and severe pain
• Treats sensitivity to light and sound; reduces nausea
• Clinical trials indicate patients experience reduction in pain within 30 minutes
• Contains safe amounts of acetaminophen, aspirin, and therapeutically active caffeine
• Please read all label information on delivery

Excedrin╜ Migraine is a non-prescription pain reliever that contains acetaminophen, aspirin and therapeutically active caffeine?. In independent studies of 1,250 patients, Excedrin Migraine was clinically proven to relieve migraine headache pain. After

List Price: $ 40.86

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• For the temporary relief of minor aches and pains
• Take for headaches, sinusitis, muscular aches, menstrual cramps, toothaches
• Contains acetaminophen, aspirin, and caffeine
• Do not take during the last 3 months of pregnancy unless directed so by doctor
• Please read all label information on delivery

For temporary relief of the pain of headache, sinusitis, colds, muscular aches, menstrual discomfort, toothache and minor arthritis pain Extra Strength Excedrin is a combination pain reliever that contains acetaminophen, aspirin and therapeutically activ

List Price: $ 40.86

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• Compare to Excedrin Caplets active ingredients
• Acetaminophen, Aspirin and Caffeine
• Pain Reliever + Pain Reliever Aid
• For the temporary relief of minor aches and pains

For temporary relief of the pain of headache, sinusitis, colds, muscular aches, menstrual discomfort, toothache and minor arthritis pain. Extra Strength Headache Relief is a combination pain reliever that contains acetaminophen, aspirin and therapeutically active caffeine. Doctors call the enhanced pain relieving effect provided by products that contain caffeine in combination with acetaminophen and aspirin “caffeine adjuvancy”. And doctors believe that these non-prescription combination pain-relief products offer major advantages for headache sufferers. Many doctors recommend a non-prescription combination pain reliever like Headache Relief as an alternative before prescription medications. Interestingly, caffeine is also an ingredient in many of the most frequently used prescription headache medications. In independent studies of patients with tension-type headache, the combination of acetaminophen, aspirin and therapeutically active caffeine was shown to provide superior pain relief over acetaminophen alone.In three clinical studies, 94% of patients needed only one dose of Extra Strength Headache Relief to relieve tension-type headache pain.

List Price: $ 12.00

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1. This is the only medicine I’ve ever found to actually work on my tension headaches. I have used it about 2 – 3 times a year for a few to several days in a row to knock out my headaches. This is my ‘last resort’ medication and for great reason – it works. As someone else posted, if this doesn’t work, nothing is going to work. I’m so thankful for this medication.

2. I have been having headaches for about five months and the doctor prescribed me Fioricet and it does nothing for my headaches.

3. I use Fioricet on regular basis and most of the time it seems to help.

4. Fioricet does wonders! It helps my tension headaches, especially when I am stressed!

5.I was getting cluster headaches for about 3 weeks. Went to ER and they gave me a shot of Stadol, but that didn’t even take my headache away. Got Fioricet prescription filled next day (today). Haven’t had a headache all day.

6.I have had almost daily headaches since I was 15. I am now 43. I would not have believed such a simple medication would have worked so well.

7.I have brain tumors and Fioricet works wonders. It makes the pain go away in about an hour. I couldn’t live without this wonder drug.

8.Works great but it does make me sleepy at first. I have found that I only have to take it once and my headache is gone for the rest of the day!

9.I have been a suffering from migraine headaches for 20 years. I’ve tried EVERYTHING. My experience has shown if you take 2 tablets of Fioricet at the onset of one, you will do yourself a huge favor. It works. It may not eliminate your migraine but it will make it tolerable and less severe. Like others above, you have to be careful about how much you do take. I’ve found if I had a bad headache and have taken several pills, I have to then ween myself off of it by taking one pill every 4 hours over the next day or so to prevent a rebound headache. If you take many of these to relieve a headache, I recommend taking a few when your headache is gone to prevent a rebound. I make sure I carry my Fioricet with me at all times.

10.Have been using this drug for about 16 years now. No other migraine medicine compares to it. Have recommended it to several other migraine sufferers. In turn they have called their doctors and now they are on it. They have had the same luck I have.

11.I was not one prone to headaches until recently. They started at the base of my neck and continued upward until I didn’t want to move a muscle. Oddly enough, these were prescribed by my dentist due to an upcoming root canal I was getting ready for. I took one the next time I had a headache and within 30 minutes it was completely gone. I was amazed.

12.BEWARE – THIS DRUG MAY GIVE REBOUND HEADACHES.

13.For the first six months it worked great but now it doesn’t relieve my headaches at all. In fact the only thing it does is gives me insomnia.

14.I have tried just about every option available and this medication has been the only one to truly relieve my headache AND allow me to feel “normal” so that I am able to function.
15.This is a wonderful drug. It takes the pain away within a few minutes and even if the migraine doesn’t go away altogether, the pain isn’t as bad as it would be or could be, without some form of medication. Believe me I’ve tried them all. I am now on Topamax 50mg twice a day, Fioricet and Midrin.

16.I GET PROBABLY 4 OR 5 MIGRAINES A MONTH. I COULDN’T BEAR TO BE WITHOUT MY FIORICET. IT’S THE ONLY MEDICINE THAT SEEMS TO WORK FOR ME. IF I FEEL A HEADACHE STARTING, I TAKE 2 TABS AND WITHIN 20-30 MINS, THE HEADACHE IS GONE. IN ADDITION TO BEING A MOTHER OF 4 GIRLS, I HAVE RUN MY FAMILY DAY CARE FOR 17 YEARS AND I JUST WOULDN’T BE ABLE TO FUNCTION WITHOUT MY FIORICET. I HAVE TRIED SEVERAL OTHER MEDICINESS BEFORE FIORICET, AND NOTHING SEEMED TO HELP SO I AM VERY THANKFUL FOR FIORICET. IT WORKS GREAT FOR ME. I’VE TRIED TO AVOID THINGS THAT SET OFF MY HEADACHES, LIKE NOT EATING BEFORE 2 PM, OR MY PILLOWS NOT BEING RIGHT WHEN SLEEPING, BRIGHTNESS, SOUNDS, SMELLS AND STRESS. BUT SOME CAN’T BE AVOIDED. THANK YOU.

This drug should not be used with the following medication because very serious interactions may occur: sodium oxybate.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting this medication.

The following drugs can interact with Fioricet. Tell your doctor if you are using any of these:

• an antibiotic;
• a blood thinner such as warfarin (Coumadin);
• isoniazid;
• zidovudine (Retrovir, AZT);
• seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton);
• gout medications such as probenecid (Benemid) or sulfinpyrazone;
• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
• steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others; or
• an antidepressant such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), and others.

This list is not complete and there may be other drugs that can interact with Fioricet. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: adenosine, anti-seizure drugs (e.g., carbamazepine, phenytoin), beta agonists (e.g., albuterol), drugs affecting liver enzymes that remove this medication from your body (such as macrolide antibiotics including erythromycin, cimetidine, disulfiram, valproic acid, fluvoxamine, MAO inhibitors including furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), isoniazid, lithium, methoxyflurane, phenothiazines (e.g., chlorpromazine).

This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include “blood thinners” (e.g., warfarin), cyclosporine, corticosteroids such as prednisone, estrogen, felodipine, metronidazole, quinidine, certain beta blockers such as metoprolol, theophylline, doxycycline.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as certain antihistamines (e.g., diphenhydramine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain caffeine or drowsiness-causing ingredients. Also keep in mind that certain beverages (e.g., coffee, colas, tea) contain caffeine. Ask your pharmacist about using those products safely.

Acetaminophen is an ingredient in many nonprescription products and in some combination prescription medications. Read the labels carefully before taking other pain relievers, fever reducers, or cold products to see if they also contain acetaminophen. Consult your pharmacist if you are uncertain whether your other prescription or nonprescription products contain acetaminophen. (See also adult maximum daily dose information in Side Effects section.)

This medication may decrease the effectiveness of combination-type birth control pills. This can result in pregnancy. Ask your doctor or pharmacist for details, and discuss whether you should use additional reliable birth control methods while taking any of these drugs.

This medication may interfere with certain medical/laboratory tests (including urine 5-HIAA levels, urine VMA levels, urine catecholamine levels, dipyridamole-thallium imaging tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Do not take more Fioricet than is recommended. An overdose of acetaminophen can cause damage to your liver. Do not use any other cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as “APAP”) is contained in many combination medicines. If you use certain products together with Fioricet you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen or APAP. Avoid drinking alcohol. It can increase the risk of liver damage while you are taking acetaminophen. If you drink more than three alcoholic beverages per day, do not take acetaminophen without your doctor’s advice, and never take more than 2 grams (2000 mg) per day.

Before taking this medication, tell your doctor or pharmacist if you are allergic to acetaminophen, caffeine, or butalbital; or to other barbiturates (e.g., phenobarbital) or xanthine derivatives (e.g., theophylline); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., bronchopneumonia), a certain enzyme disorder (porphyria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, personal or family history of regular use/abuse of drugs/alcohol, mental/mood disorders, abdominal/stomach problems (e.g., stomach ulcer), heart disease (e.g., irregular heartbeat, recent heart attack).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Liquid products may contain alcohol, sugar and/or aspartame. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

This product contains acetaminophen, which may cause liver damage. Daily use of alcohol, especially when combined with acetaminophen, may increase your risk for liver damage. Avoid alcohol. Check with your doctor or pharmacist for more information.

Before having surgery, tell your doctor or dentist that you are using this medication.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication for an extended time may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, seizures, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn.

This drug passes into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.

Butalbital may be habit-forming and should be used only by the person it was prescribed for. Fioricet should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Do not take Fioricet without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

You should not take Fioricet if you are allergic to acetaminophen, butalbital, or caffeine, or if you have porphyria.

Before using Fioricet, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease,
• liver disease; or
• a history of mental illness or suicidal thoughts.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Fioricet.

FDA pregnancy category C. It is not known whether Fioricet is harmful to an unborn baby. Before taking Fioricet, tell your doctor if you are pregnant or plan to become pregnant during treatment. Acetaminophen, butalbital, and caffeine can pass into breast milk and may harm a nursing baby. Do not use Fioricet without telling your doctor if you are breast-feeding a baby.

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Fioricet, a strong, non-narcotic pain reliever and relaxant, is prescribed for the relief of tension headache symptoms caused by muscle contractions in the head, neck, and shoulder area. It combines a sedative barbiturate (butalbital), a non-aspirin pain reliever (acetaminophen), and caffeine. Mental and physical dependence can occur with the use of barbiturates such as butalbital when these drugs are taken in higher than recommended doses over long periods of time.

Fioricet and Esgic are brand name drugs made from a combination of butalbital (a barbiturate, 50 mg), acetaminophen (325 mg), and caffeine (40 mg). They are indicated for the treatment of tension headaches and muscle contraction headaches. Although not indicated, they are commonly used to treat migraines and other pain related ailments. Note that Fioricet (and some other pain medications) are implicated as causing repeat headaches with over-use (see NYT citation below)

Butalbital has generalized depressant effect on central nervous system and, in very high doses, has peripheral effects. Acetaminophen has analgesic and antipyretic effects; its analgesic effects may be mediated through inhibition of prostaglandin synthetase enzyme complex. Caffeine is thought to produce constriction of cerebral blood vessels.

Butalbital has a half-life of about 35 hours. Acetaminophen has a half-life of about 1.25 to 3 hours, but may be increased by liver damage and after an overdose. Caffeine has a half-life of about 3 hours.

What is the most important information I should know about acetaminophen, butalbital, and caffeine?

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take acetaminophen, butalbital, and caffeine before the MAO inhibitor has cleared from your body. Do not take more of this medication than is recommended. An overdose of acetaminophen can cause damage to your liver. Do not use any other cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as “APAP”) is contained in many combination medicines. If you use certain products together you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen or APAP. Avoid drinking alcohol. It can increase the risk of liver damage while you are taking acetaminophen. If you drink more than three alcoholic beverages per day, do not take acetaminophen without your doctor’s advice, and never take more than 2 grams (2000 mg) per day.

Butalbital may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Do not take this medication without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

You should not take this medication if you are allergic to acetaminophen, butalbital, or caffeine, or if you have porphyria.

Before using acetaminophen, butalbital, and caffeine, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease,
• liver disease; or
• a history of mental illness or suicidal thoughts.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. It is not known whether acetaminophen, butalbital, and caffeine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Acetaminophen, butalbital, and caffeine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

What is the most important information I should know about acetaminophen, butalbital, and caffeine?

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take acetaminophen, butalbital, and caffeine before the MAO inhibitor has cleared from your body. Do not take more of this medication than is recommended. An overdose of acetaminophen can cause damage to your liver. Do not use any other cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as “APAP”) is contained in many combination medicines. If you use certain products together you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen or APAP. Avoid drinking alcohol. It can increase the risk of liver damage while you are taking acetaminophen. If you drink more than three alcoholic beverages per day, do not take acetaminophen without your doctor’s advice, and never take more than 2 grams (2000 mg) per day.